Practices that show potential to achieve desirable public health outcomes in a specific real-life setting and produce early results that are consistent with the objectives of the activities and thus indicate effectiveness.

Differential COVID-19 mortality in the United States: Patterns, causes, and policy implications

Stoto, M. A., Schlageter, S., Gamannossi degl'Innocenti, D., Zollo, F., Kraemer, J. D.

Release Date:

Systematic Review/Meta-Analysis

Data Collection and Analysis
Policy Change/ Development
Social and Community Context
Tools Included
Outside U.S.

Mitigation and Prevention

This analysis explores regional variation in COVID-19 death rates across America. It unpacks the “two Americas” narrative of some parts of the country having high demand for vaccines and others having widespread vaccine hesitancy, and shows that a divide between rates of exceeds death existed prior to the introduction in vaccines. This difference is likely due to a difference in mask use, social distancing, and other behaviors. Results underscore the importance of excess mortality measures such as wastewater testing to get a more accurate picture.

Resource Details

Outcomes of Interest

Reduction of Health Disparities

Priority Population(s)

Setting(s) of Implementation


Geographic Area of Implementation

Implementation Period